Isopropyl Alcohol Inhalation for Nausea
#1
A recent randomized, double-blinded, placebo-controlled trial by Beadle et al. was performed in an ED population complaining of nausea and/or emesis comparing saline versus isopropyl alcohol inhalation. This study found that isopropyl alcohol provided significantly greater relief from nausea in the first 10 minutes of aromatherapy compared to saline (p <0.001).  The mechanism of action is unknown.  Treatment involves three nasal inhalations of a standard ED alcohol wet wipe every 15 minutes, repeated two times as needed.

[*]Cotton JW, Rowell LR, Hood RR, Pellegrini JE. A comparative analysis of isopropyl alcohol and ondansetron in the treatment of postoperative nausea and vomiting from the hospital setting to the home. AANA J. 2007; 75(1): 21-6. PMID: 17304779
[*]Winston AW, Rinehart RS, Riley GP, Vacchiano CA, Pellegrini JE. Comparison of inhaled isopropyl alcohol and intravenous ondansetron for treatment of postoperative nausea. AANA J. 2003; 71(2): 127-32. PMID: 12776641
[*]Egerton-Warburton D, Meek R, Mee MJ, Braitberg G. Antiemetic use for nausea and vomiting in adult emergency department patients: randomized controlled trial comparing ondansetron, metoclopramide, and placebo. Ann Emerg Med. 2014; 64(5): 526-532.e1. PMID: 24818542
[*]Pellegrini J, DeLoge J, Bennett J, Kelly J. Comparison of inhalation of isopropyl alcohol vs promethazine in the treatment of postoperative nausea and vomiting (PONV) in patients identified as at high risk for developing PONV. AANA J. 2009; 77(4): 293-9. PMID: 19731848
[*]Merritt BA, Okyere CP, Jasinski DM. Isopropyl alcohol inhalation: alternative treatment of postoperative nausea and vomiting. Nurs Res. 2002; 51(2): 125-8. PMID: 11984383
[*]Smiler BG, Srock M. Isopropyl alcohol for transport-related nausea. Anesth Analg. 1998; 87(5): 1214. PMID: 9806717
[*]Hines S, Steels E, Chang A, Gibbons K. Aromatherapy for treatment of postoperative nausea and vomiting. Cochrane Database Syst Rev. 2012; 4: CD007598. PMID: 22513952
[*]Wang SM, Hofstadter MB, Kain ZN. An alternative method to alleviate postoperative nausea and vomiting in children. J Clin Anesth. 1999; 11(3): 231-4. PMID: 10434220
[*]Beadle KL, Helbling AR, Love SL, April MD, Hunter CJ. Isopropyl Alcohol Nasal Inhalation for Nausea in the Emergency Department: A Randomized Controlled Trial. Ann Emerg Med. 2015; DOI: http://dx.doi.org/10.1016/j.annemergmed.2015.09.031



Notes from https://www.aliem.com/2015/trick-trade-i...-vomiting/
"They that are whole have no need of the physician, but they that are sick" -  Jesus of Nazareth
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