Ofloxacin for traumatic TM perforation
#1
http://www.ncbi.nlm.nih.gov/pubmed/27105974
http://www.ncbi.nlm.nih.gov/pubmed/26463556
http://emedicine.medscape.com/article/858684-treatment

The effect of ofloxacin otic drops on the regeneration of human traumatic tympanic membrane perforations. These studies show positive results. A retrospective study of patients with traumatic tympanic membrane perforation greater than one quarter the size of the membrane found that topical application of either epidermal growth factor (EGF) or ofloxacin otic drops reduced healing time over that associated with observation.  Healing with EGF and ofloxacin otic drops took a mean 12.6 and 12.9 days, respectively, compared with 35.7 days for observation. 

The first study says that the "closure rate" was not significantly different between the observation and treatment groups but the "closure time" was significantly decreased.  I'm going to have to read this paper more to understand "closure rate. The second study makes the point that they think the decreased closure time is due only to the "moist environment" resulting from the frequent use of ear drops.

1. Jian-Yang, Zi-Han-Lou, Yahui-Fu, Zheng-Cai-Lou. A retrospective study of EGF and ofloxacin drops in the healing of human large traumatic eardrum perforation. Am J Otolaryngol. 2016 Mar 22.
2. Lou Z, Lou Z, Tang Y, Xiao J. The effect of ofloxacin otic drops on the regeneration of human traumatic tympanic membrane perforations. Clin Otolaryngol. 2015 Oct 14.
"They that are whole have no need of the physician, but they that are sick" -  Jesus of Nazareth
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