Sulfate Deficiency?
#1
     During the 1980's environmemtalist who today are warning about global warming were decrying acid rain.  The consequence of the "acid rain" movement was to significantly reduce the amount of sulfate in coal, oil and gasoline as well as their combustion products. Billions of dollars were spent on this policy and the consequences to soil sulfate levels according to the graphic are pronounced. 

Scientific studies demonstrate that if sulfate is not in the soil, it is not incorporated into the plants. Sulfate is not legally required and not routinely added to soil either.  BigAg finds using NH4NO3 is cheaper than NH4SO4 because they get twice the nitrogen per pound. Also, using Alum as a flocculant in drinking water actually decreases overall sulfate content of water.  All the sulfate coagulates and precipitates out of solution and may be the mechanism of how Alum serves as an adjuvant in vaccines. 

Over the last 100 years, we have seen an explosion of chronic inflammatory illnesses from lupus to crohns disease, asthma, and even hypertension, diabetes, and heart disease.  Some argue that these inflammatory disorders were always there but we are seeing more of them today because people are living longer today and we are recognizing them better.

All these modern chronic inflammatory diseases have something in common. They all are associated with elevated homocysteine levels.  Accordingly, homocysyeine is considered a nonspecific marker of inflammation.  But, thats just it.  Homocysteine is not nonspecific. Homocysteine is a very specific biochemical intermediate in the sulfur and DNA repair pathway.  Could it be that elevated homocysteine is pointing us directly to what the problem is-- Sulfate deficiency?
"They that are whole have no need of the physician, but they that are sick" -  Jesus of Nazareth
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#2
This was very informative post. Cholesterol sulfate deficiency may lead to filaggrin and instability of blood. Its deficiency may contribute to many health and skin conditions.
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#3
Sulfate (SO4^2-) is used all over in the body for many things. It is one of the most important negative ions (anions) in the body after chloride (Cl-) and bicarbonate (CO3^2-).  Sulfate is used to make other more complex molecules more soluble.  The liver conjugates toxins and drugs with sulfate so they can be excreted by the kidney.  Similarly, many important complex molecules in the body are sulfated to increase their solubility.

You might have heard of the good cholesterol that is in egg yokes is also found in our brain.  Or you might have taken glucosamine and chondroitin for your joints.  An important natural blood thinner is heparin and heparan.  However, cholesterol, heparin and glucosamine are not active on their own. Cholesterol sulfate, glucosamine sulfate, chondroitin sulfate, dermantan, heparan, and heparin must be sulfated to be active.  Without sulfate, the body cannot produce or utilize these important biomolecules called glycosaminoglycans.  Decreased sulfate levels can lead to all sorts of health problems from cancers, to autoimmune diseases, dementia, mental illness, type 2 diabetes, and blood clots like heart attacks, stroke and pulmonary embolism. 

You might also have also heard of glutathione.  Glutathione (GSH) is the master antioxidant for each cell. Glutathione protects the cell from oxidative damage. When dietitians tell us to eat a diet of fresh fruits and veggies rich in antioxidants, those antioxidant keep glutathione in its protective state.  Glutathione is chock full of sulfur amino acids.  You could consume all the antioxidants possible, but without sulfate you wouldn't produce the glutathione for the other antioxidants to keep active.

Humans get sulfate in two ways.  First, we can directly consume inorganic sulfate.  The body easily absorbs sulfate and distributes it throughout the body.  Second, if there is not enough inorganic sulfate in the diet, the body can convert sulfur-containing amino acids in protein like methionine and cysteine into sulfate. In fact, despite the importance of sulfate to our health, the FDA makes absolutely no recommendations for our daily sulfate requirement. Sadly, the government considers sulfate to be a acid rain-causing pollutant and has gone to great lengths to scrub it out of our coal and gasoline.

The FDA assumes that we can just get all the sulfate we need by converting sulfur amino acids into sulfate. The problem with this is that converting methionine and cysteine in protein to sulfate is very expensive and requires B12, B6, and folate to do the transformation.
"They that are whole have no need of the physician, but they that are sick" -  Jesus of Nazareth
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