EMERGCITY - Emergency Medicine Physician Forum
Tranexamic Acid - Printable Version

+- EMERGCITY - Emergency Medicine Physician Forum (http://emergcity.com)
+-- Forum: EM Physician Forum (http://emergcity.com/forumdisplay.php?fid=1)
+--- Forum: General Discussion (http://emergcity.com/forumdisplay.php?fid=5)
+--- Thread: Tranexamic Acid (/showthread.php?tid=84)



Tranexamic Acid - dbrosnahan - 02-10-2017

Tranexamic Acid is a cheap and effective medicine to control bleeding after trauma, during surgery, for epistaxis and for heavy vaginal bleeding. The Crash-2 Trial showed significant decrease in all-cause mortality and death by hemorrhage.  The dose for TXA is 1 gm IV immediately and then 1 gm IV over the next 8 hours.  For epistaxis, nasal packing can be soaked in TXA. For menorrhagia, the dose is 1300 mg daily TID for 5 days.

https://www.ncbi.nlm.nih.gov/pubmed/23477634

While statistically significant, the decrease in all-cause mortality and death from hemorrhage with TXA in the Crash-2 study was only from 16% to 14.5% and 5.7% to 4.9% respectively.